2 april 2021 – Inreda illustrates studies with the AP
Welcome to our first news letter in 2021.
In this news letter, we would like to tell you about the studies that we have performed. These studies have already been completed, but we did not stand still since then and we are going on with developing the device. Now and in the future, we will continue performing studies for different kinds of purposes. Always striving to make the artificial pancreas available for everyone who is in need of it. And to optimize and refine the device perpetually.
Publication results APPEL5 study
In the first week of January this year, Diabetes Care (medical scientific magazine published by the American Diabetes Association) has published the results of the APPEL5 (CE) study.
Title: Fully Closed Loop Glucose Control With a Bihormonal Artificial Pancreas in Adults With Type 1 Diabetes: An Outpatient, Randomized, Crossover Trial Authors: Helga Blauw, A. Joannet Onvlee, Michel Klaassen, Arianne C. van Bon, and J. Hans DeVries (Amsterdam UMC location AMC, Inreda Diabetic, Rijnstate hospital Arnhem)
The aim of the study was to demonstrate the performance and safety of a bi-hormonal (insulin and glucagon) artificial pancreas in adults with type 1 diabetes. In this randomized cross-over study in a home situation, a 2-week fully closed-loop glucose control (AP treatment) was compared with 2-week open-loop control (the patient's normal insulin pump treatment with a glucose sensor if they had one).
A total of 23 patients were included in the analysis. With the AP, the mean time in range was 86.6% while it was 53.9% during the control period. Except for one patient, the AP yielded an improvement in the time in range for all participants. Because the AP continuously measures and regulates the blood glucose, tailor-made insulin is dosed much more often, so that the final time in range is higher than if an insulin bolus is only given at specific times. Especially during the night (between 0:00 and 7:00am) the AP was very well able to regulate the blood glucose: an average time in range of 97.1% compared to 48.1% during the control period.
Study APPEL5+ for people with diabetes type 3
Colleague in the spotlight
Who are you?
I am Mickael Boulay. In 2012, I graduated from the Design Academy in Eindhoven, in Man & Well-being. After my studies I worked at Waag Society in Amsterdam. I was affiliated with the Creative Care Lab, which deals with projects primarily focused on healthcare, such as low-cost prosthetic legs and a new interface for Inreda's AP. Later, I started working part-time and then full-time at Inreda.
What do you do?
At Inreda I am now responsible for the Design department. This relatively new department supports Inreda in the field of design and customer experience to ensure a great and consistent Inreda customer journey (that is the entire journey of a customer: from 'not yet being a customer' to 'using the AP daily'). Our motto is user-centered design: people come first and that is applied on all fronts. So, of course, used for the design or user-friendliness of the artificial pancreas, but also for the associated services, training materials, printing, website and other digital environments, etc. In addition, we explore, within various projects (often in collaboration with external partners) , future opportunities to further improve the use of the AP and the customer experience.
Do you have a passion for something?
What do you do in your spare time?
.I like to do a lot of creative things with my kids, like building crazy things from Lego. I also like to go mountain biking in the woods. Sometimes I go alone, but more and more often with my son (we call that an 'expedition', with sandwiches and all!).
How did you get a job at Inreda?
I started at Inreda from my previous work at Waag Society. In 2013, I watched television with my colleagues and saw a man who said that he had 'just' built an artificial pancreas. This was Robin Koops, at the table at the live talk show ‘De Wereld Draait Door’ (the world turns and turns). We thought it would be nice to talk to him and to contribute to that. We called him and agreed to work on the user interface of the artificial pancreas. To be able to do that and to strengthen the then still small team, I went 1 or 2 days a week from Amsterdam to Inreda in Goor. Later, I switched full-time to be able to contribute even more to this innovative challenge!
Has something fun, crazy or memorable happened at work?
After all the developments at the AP in recent years, it is now being used as a new treatment in collaboration with a number of hospitals and a health insurance company. The AP is now used, as we speak, by people in everyday life. When I look back on this we have done a lot, and when I look to the future: we want to achieve even more and make the device available to even more people! This is what drives me (and I think everyone at Inreda) to start your work full of energy every day and do the best to go one step further!